Director of rugby Dai Young hands first Wasps starts of the season to Ben Morris, Joe Simpson and Marcus Watson as the club play Newcastle Falcons at Kingston Park on Friday.
There are six changes to the starting 15 from Saturday’s win against Sale Sharks.
New signing Morris replaces Nathan Hughes, who is named among the replacements alongside Elliot Daly and Dan Robson, the trio having been involved in England’s training camp this week. Morris joins captain Ashley Johnson and Nizaam Carr, who moves to number eight, in the back row.
Simpson swaps in for Robson, to form the half back partnership with Lima Sopoaga. Outside them Juan De Jongh replaces Daly, having passed his HIA protocols, to partner Michael Le Bourgeois in the centres.
Watson returns from illness last week to replace Christian Wade on the wing and is joined in the back three by Josh Bassett and Rob Miller, replacing Willie Le Roux who is on Springbok duty.
Tom Cruse rotates with Tommy Taylor and is joined by an unchanged prop pairing of Zurabi Zhvania and Will Stuart in the front row. Behind them Will Rowlands and James Gaskell form the lock partnership for the second week in a row.
Daly, Hughes and Robson are joined on a powerful bench by Taylor, Ben Harris, Kieran Brookes, Kearnan Myall and Billy Searle.
Director of Rugby Dai Young said:
"Defensively Newcastle take a lot of breaking down. We will need to keep the ball for multiple phases. They don't get broke much off first phase, you've got to look after the ball.
"Set-piece wise we will be tested. They've got a lot of the old Leicester tradition in Newcastle, but the way they play the game is exciting as well. They play the ball with real width moving it from one touchline to another looking for opportunities.
“They've certainly got some real weapons out wide. We know it's going to be a tough game. They've played all the big boys and I think they've been a bit unlucky, they've pushed them close, we know it's going to be a tough match for us.
"It's two back-to-back six-day turnarounds with a travel day thrown in there which isn't easy. But if we play the way we know we can play, there's no reason why we can't come away with a result which would be fantastic for us to get."
Tickets for Wasps’ next home game at the Ricoh Arena against Gloucester Rugby are priced from £15 and are available by visiting the Ricoh Arena ticket office, going to www.wasps.co.uk/tickets or calling 02476 786411.
Under 10s go free in most areas of the Ricoh Arena.
Wasps team to face Newcastle Falcons at Kingston Park on Friday September 28 (7:45pm kick off)
15 Rob Miller
14 Marcus Watson
13 Juan De Jongh
12 Michael Le Bourgeois
11 Josh Bassett
10 Lima Sopoaga
9 Joe Simpson
1 Zurabi Zhvania
2 Tom Cruse
3 Will Stuart
4 Will Rowlands
5 James Gaskell
6 Ashley Johnson (c)
7 Ben Morris
8 Nizaam Carr
16 Tommy Taylor
17 Ben Harris
18 Kieran Brookes
19 Kearnan Myall
20 Nathan Hughes
21 Dan Robson
22 Billy Searle
23 Elliot Daly