Conor O'Shea has picked Wasps' Michele Campagnaro in the Italy team to face Scotland at BT Murrayfield Stadium in Edinburgh on Saturday 2 February.
Campagnaro starts on the left wing in the opening weekend of the Guinness Six Nations 2019.
The match sees the return of the Azzurri captain Sergio Parisse to the starting line up, having been on the sidelines in November for injury. Parisse returns for his hundred and thirty-fifth cap for Italy and his sixty-sixth appearance of the Six Nations, a record for the tournament.
Vice-captain Leonardo Ghiraldini will also celebrate his hundredth international cap, becoming the eighth Italian reach a century of apperances.
David Sisi, the 25 year-old second row from Zebre Rugby Club, makes his debut.
15 Jayden Hayward (Benetton Rugby, 12 caps)
14 Angelo Esposito (Benetton Rugby, 15 caps)
13 Luca Morisi (Benetton Rugby, 20 caps)
12 Tommaso Castello (Zebre Rugby Club, 15 caps)
11 Michele Campagnaro (Wasps Rugby, 38 caps)
10 Tommaso Allan (Benetton Rugby, 43 caps)
9 Tito Tebaldi (Benetton Rugby,29 caps)
8 Sergio Parisse (Stade Francais, 134 caps) – capitano
7 Abraham Steyn (Benetton Rugby, 25 caps)
6 Sebastian Negri (Benetton Rugby, 12 caps)
5 Dean Budd (Benetton Rugby, 16 caps)
4 David Sisi (Zebre Rugby Club, esordiente)
3 Simone Ferrari (Benetton Rugby, 17 caps)
2 Leonardo Ghiraldini (Stade Toulosain, 99 caps)
1 Andrea Lovotti (Zebre Rugby Club, 30 caps)
16 Luca Bigi (Benetton Rugby, 15 caps)
17 Cherif Traore (Benetton Rugby, 5 caps)
18 Tiziano Pasquali (Benetton Rugby, 13 caps)
19 Federico Ruzza (Benetton Rugby, 7 caps)
20 Jimmy Tuivaiti (Zebre Rugby Club, 1 cap)
21 Guglielmo Palazzani (Zebre Rugby Club, 28 caps)
22 Ian McKinley (Benetton Rugby, 4 caps)
23 Edoardo Padovani (Zebre Rugby Club, 15 caps)