Elliot Daly will make his first international start in the full back shirt when England face the Barbarians at Twickenham on Sunday at 3pm.
He is joined in the starting line-up by his club captain Joe Launchbury, while Wasps' half-backs from last Saturday's Aviva Premiership semi-final, Dan Robson and Danny Cipriani, are named on the bench.
George Ford (Leicester) and Chris Robshaw (Harlequins) reprise the co-captaincy roles they previously shared against the same opponents 12 months ago and Samoa during this season's autumn series.
Ford's club partner Ben Youngs returns at scrum half following a knee injury sustained against Italy in the Six Nations.
Mike Brown (Harlequins) and Jonny May (Leicester) join Daly in the back three while Northampton's Piers Francis partners the uncapped Henry Trinder (Gloucester) in midfield.
Robshaw, Tom Curry (Sale Sharks) and Bath's former England U20 captain Zach Mercer form the back row, while his club-mate Elliot Stooke partners Launchbury in the engine room.
Harlequins' props Kyle Sinckler and Joe Marler are joined by Worcester hooker Jack Singleton in the front row.
Head coach Eddie Jones believes the Barbarians contest, for which caps are not awarded, represents a good test for a squad which is without Saracens and Exeter players who are involved in tomorrow's Premiership final.
“This is a good young squad and their work ethic has been outstanding over the last two weeks," he said.
"Their application to learn has been very good but they are very young at test rugby level so this week’s match against the Barbarians is a fantastic opportunity for them to step up.
“It is a great opportunity for them to show they deserve to wear the English rose, to show they can be in contention for the World Cup and a great opportunity for them to put us on the front foot ahead of the South Africa tour.
“You never know what to expect from the Barbarians team. We know they will be well coached by Pat Lam, we know they have got good individual players and some outstanding individual players, so we need to be up for the unexpected.
“We can’t wait to get back to Twickenham and get on the front foot, please the fans and play some good rugby.”
Quilter Cup: England side to play Barbarians
15 Elliot Daly (Wasps, 18 caps)
14 Jonny May (Leicester Tigers, 34 caps)
13 Henry Trinder (Gloucester Rugby, uncapped)
12 Piers Francis (Northampton Saints, 3 caps)
11 Mike Brown (Harlequins, 69 caps)
10 George Ford (Leicester Tigers, 45 caps)
9 Ben Youngs (Leicester Tigers, 74 caps)
1 Joe Marler (Harlequins, 56 caps)
2 Jack Singleton (Worcester Warriors, uncapped)
3 Kyle Sinckler (Harlequins, 10 caps)
4 Elliott Stooke (Bath Rugby, uncapped)
5 Joe Launchbury (Wasps, 52 caps)
6 Chris Robshaw (Harlequins, 64 caps)
7 Tom Curry (Sale Sharks, 1 cap)
8 Zach Mercer (Bath Rugby, uncapped)
16 George McGuigan (Leicester Tigers, uncapped)
17 Ellis Genge (Leicester Tigers, 5 caps)
18 Nick Schonert (Worcester Warriors, uncapped)
19 Josh Beaumont (Sale Sharks,uncapped)
20 Mark Wilson (Newcastle Falcons, 2 caps)
21 Dan Robson (Wasps, uncapped)
22 Danny Cipriani (Wasps, 14 caps)
23 Denny Solomona (Sale Sharks, 2 caps)