Moates, the scrumhalf, suffered an ACL injury in last weekend’s game against Grenoble and will need surgery. His return to play timeframe has been set at 6-9 months.
Jacobs, the centre, badly damaged ankle ligaments in the same game and he also requires surgery. He is likely to be out for a minimum of six months.
London Wasps Director of Rugby Dai Young said: “It’s a huge shame to lose two players for the remainder of the season in one go and it’s a real blow to Jack and Ben. I know they will be working incredibly hard with our medical team to get back right.”