A number of players, including Carlo Festuccia, Esteban Lozada, Nathan Hughes and Rory Pitman, who all arrived at the Club over the summer, will be making their debut appearances in black and gold.
Tommy Bell, James Cannon and Joe Carlisle all make the trip, having benched at Twickenham at the weekend while there's a healthy contingent from the London Wasps Academy squad, with Liam O'Neill, Tom Howe and Alex Harrison all in the starting line-up.
Billy Moss guests from London Welsh to make up the front row while on the bench there are also a few guest players as the Club makes use of its strong rugby links in and around London.
London Wasps team:
1.Billy Moss (London Welsh)
7.Matt Everard (C)
8. Rory Pitman
16.Kevin Davis (Guest from London Welsh)
17.Jamie Kilbane (Guest from London Scottish)
18.Harry Williams (Academy)
19.Ben West (Guest from London Welsh)
20.Gus Jones (Academy)
21.Callum Grant (Guest from Rosslyn Park)
22.Gus Patterson (Guest from Rosslyn Park/RAF)
23.Louis Clayton-Molloy (Academy)