On Friday night, England Saxons take on Scotland A at Kingston Park (20:00) with two Wasps named in the squad; Elliot Daly once again named to start at fullback and Joe Simpson included among the replacements.
Having recently announced his move to London Wasps next season, Matt Mullan also earns a start, replacing Nick Wood at loosehead prop.
The only other change from the side that beat the Irish Wolfhounds sees Jonny May start in the place of Christian Wade.
On Saturday, England face Scotland in their opening fixture of the 2013 Six Nations at Twickenham Stadium (16:00). Joe Launchbury has been named in the starting line-up for England, with fellow Wasp James Haskell among the replacements.
That side sees only two changes from the team that started against New Zealand in December, with Billy Twelvetrees and Joe Marler replacing Manusamoa Tuilagi and Alex Corbisiero respectively.
On the bench, Dylan Hartley, Toby Flood and David Strettle come into the side in the place of David Paice, Freddie Burns and Jonathan Joseph.
England Saxons (v Scotland A, Friday, 8pm, Kingston Park)
15 Elliot Daly (London Wasps)
14 Jonny May (Gloucester Rugby)
13 Joel Tomkins (Saracens)
12 Jordan Turner-Hall (Harlequins)
11 Tom Biggs (Bath Rugby)
10 George Ford (Leicester Tigers)
9 Richard Wigglesworth (Saracens)
1 Matt Mullan (Worcester Warriors)
2 Joe Gray (Harlequins)
3 Paul Doran-Jones (Northampton Saints)
4 Graham Kitchener (Leicester Tigers)
5 George Robson (Harlequins)
6 George Kruis (Saracens)
7 Will Fraser (Saracens)
8 Jordan Crane (Leicester Tigers, captain).
16 Rob Buchanan (Harlequins)
17 Nick Wood (Gloucester Rugby)
18 Kieran Brookes (Leicester Tigers)
19 Ed Slater (Leicester Tigers)
20 Jamie Gibson (London Irish)
21 Joe Simpson (London Wasps)
22 George Lowe (Harlequins)
23 Kyle Eastmond (Bath Rugby)
England (v Scotland, Saturday, 4pm, Twickenham Stadium)
15. Alex Goode (Saracens)
14. Chris Ashton (Saracens)
13. Brad Barritt (Saracens)
12. Billy Twelvetrees (Gloucester Rugby)
11. Mike Brown (Harlequins)
10. Owen Farrell (Saracens)
9. Ben Youngs (Leicester Tigers)
1. Joe Marler (Harlequins)
2. Tom Youngs (Leicester Tigers)
3. Dan Cole (Leicester Tigers)
4. Joe Launchbury (London Wasps)
5. Geoff Parling (Leicester Tigers)
6. Tom Wood (Northampton Saints)
7. Chris Robshaw (Harlequins, capt)
8. Ben Morgan (Gloucester Rugby)
16. Dylan Hartley (Northampton Saints)
17. David Wilson (Bath Rugby)
18. Mako Vunipola (Saracens)
19. Courtney Lawes (Northampton Saints)
20. James Haskell (London Wasps)
21. Danny Care (Harlequins)
22. Toby Flood (Leicester Tigers)
23. David Strettle (Saracens)