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Alex King made a man-of-the-match comeback against Northampton at Loftus Road to get the Black and Gold's season back on track, after last week's defeat at Newcastle.
Saints in contrast slumped to a fourth defeat in five games on the road.
Lawrence Dallaglio set the scene for a one-sided encounter, touching down after just seven minutes, and Wasps never looked back.
The Londoners secured a bonus point inside an hour when lock Andy Reed collected try number four, giving Northampton a king-sized headache ahead of tackling Biarritz in France on Saturday.
Wasps fly half Alex King, making his first start of the season after injury, gave a master-class in controlling proceedings behind Wasps' rampant pack.
King scored two tries and Wasps finished with seven in total, recording an emphatic victory which lifted them to fourth in the Premiership behind leaders Saracens, Newcastle and Leicester.
Wasps, who beat Northampton to take the Tetley's Bitter Cup at Twickenham last season, played with a precision and purpose that left the Saints a distant second-best. Northampton were never in the game, trailing 24-3 at half-time and then capitulating even further.
A second-half penalty try and wing Luca Martin's opportunist breakaway score, provided scant consolation.
Wasps started at a frantic pace, hell-bent on removing that Newcastle result from their system and, after wing Kenny Logan had kicked an early penalty, Dallaglio was driven over 10 metres from a line-out.
Northampton fly-half Mark Tucker briefly reduced the arrears with a penalty, but two further Logan strikes gave Wasps a comfortable lead inside the opening quarter.
Northampton only briefly enjoyed territorial dominance, and Wasps effectively took the game out of their reach through tries before the break by outstanding flanker Paul Volley and pacy fullback Josh Lewsey.
Wasps, having done the hard work to build up such a commanding interval lead, were in no mood to switch off after the break. Referee Brian Campsall awarded Saints a 54th minute penalty try, but there was no stopping the home side after that.
Reed, King and hooker Trevor Leota all claimed tries during a prolific 14-minute period, and it was King who fittingly brought up the half-century with a seventh touchdown in injury time.
Wasps, can now kick off their European campaign away to Swansea on Saturday quietly confident of making an impact from a qualifying group that also includes French champions Stade Francais and Italian outfit L'Aquila.
LONDON WASPS : 53
Tries: Reed, King 2, Dallaglio, Leota, Volley, Lewsey
Cons: Logan 3
Pens: Logan 4
Wasps: Lewsey, Roiser, Denney, Henderson, Logan, King, Wood, Molloy, Leota, Green, Reed, Shaw, Worsley, Volley, Dallaglio.
Replacements: Page, Waters, Leek, Beardshaw, Del Valle, Macer, Le Chevalier.
NORTHAMPTON SAINTS : 17
Tries: Martin, penalty try
Cons: Tucker 2
Northampton: Webster, Martin, Bateman, Kirk, Cohen, Tucker, Malone, Pagel, Brotherstone, Stewart, Phillips, Brouzet, Hunter, Pountney, Lam.
Replacements: Thompson, Scelzo, Rodber, Seely, Bramhall, Vass, Allan.