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Wasps ran in six tries, including one for Paul Sampson, who is now joint top try scorer in the Premiership with eleven tries.
"We played very well," said Nigel Melville afterwards. "I'm very pleased with the attitude of the players, they worked very hard last night and got the result they deserved."
Wasps picked up a further bonus point for scoring six tries, something have started to do with more consistency.
"It's always useful to get the bonus points. Plus we are playing well and the conditions have turned to our favour. The weather has been pretty poor and the surfaces away from home have been tough to play on. But I think here at Loftus Road it gives us a chance to get those extra points."
The win, in front of a season's record crowd at Loftus Road of 12,000, was marred by the sin-binning of Lawrence Dallaglio for killing the ball. But the boss has no real complaints about the decision
"The referee has ajudged that he was killing ball, even though he was actually pushed around the side. But that is the way it goes, because he sometimes gets caught in those positions, particularly when we're under a bit of pressure, so we can't really complain."
Wasps must now go to Sale and turn in a similar performance if they are to hang on to second spot. Bath who are just four points behind, travel to Rotherham, and will be odds on to come away with four points, or perhaps five if they grab a bonus.